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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2A
All Species:
14.24
Human Site:
S1332
Identified Species:
22.38
UniProt:
P11388
Number Species:
14
Phosphosite Substitution
Charge Score:
0.21
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11388
NP_001058.2
1531
174385
S1332
K
F
T
M
D
L
D
S
D
E
D
F
S
D
F
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
T1379
A
A
E
R
P
K
Y
T
F
D
F
S
E
E
E
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
T1365
A
A
E
R
P
K
Y
T
F
D
F
S
E
E
E
Dog
Lupus familis
XP_537646
1532
174610
D1333
F
T
V
D
L
D
L
D
D
S
F
S
D
F
E
Cat
Felis silvestris
Mouse
Mus musculus
Q01320
1528
172859
S1328
K
F
T
V
D
L
D
S
D
E
D
F
S
G
L
Rat
Rattus norvegicus
P41516
1526
173202
S1328
K
F
T
A
D
L
D
S
D
D
D
F
S
G
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519680
1746
195650
S1362
K
Y
T
V
D
L
S
S
D
S
D
S
S
D
S
Chicken
Gallus gallus
O42130
1553
174974
N1354
Y
Q
E
N
S
E
G
N
T
D
S
D
T
T
S
Frog
Xenopus laevis
NP_001082502
1579
178601
S1347
E
E
S
A
K
E
E
S
S
L
K
K
S
I
D
Zebra Danio
Brachydanio rerio
NP_001003834
1574
177254
E1341
K
Y
S
L
S
S
S
E
D
E
F
D
D
F
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
A1248
I
K
K
M
A
A
A
A
K
V
A
Q
A
A
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
D1317
K
V
K
K
E
G
Q
D
I
K
K
F
M
S
P
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
P1249
R
E
E
T
K
P
S
P
Y
G
R
R
V
A
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
M1266
T
E
A
S
H
S
A
M
D
T
D
N
N
V
A
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
L1230
D
K
N
F
E
R
I
L
L
E
Q
K
L
V
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
67.2
67.5
93.6
N.A.
89
88.7
N.A.
71.3
76.3
70.7
67.9
N.A.
51.2
N.A.
53
58.9
Protein Similarity:
100
78.6
78.4
96.4
N.A.
93.6
93.2
N.A.
79.1
85
81.8
78.8
N.A.
66.8
N.A.
70.4
73.4
P-Site Identity:
100
0
0
6.6
N.A.
80
73.3
N.A.
60
0
13.3
20
N.A.
6.6
N.A.
13.3
0
P-Site Similarity:
100
20
20
6.6
N.A.
86.6
80
N.A.
73.3
20
33.3
40
N.A.
20
N.A.
26.6
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
45
42.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
61.4
60.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
14
14
7
14
7
7
14
7
0
0
7
0
7
14
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
0
0
7
27
7
20
14
47
27
34
14
14
14
7
% D
% Glu:
7
20
27
0
14
14
7
7
0
27
0
0
14
14
20
% E
% Phe:
7
20
0
7
0
0
0
0
14
0
27
27
0
14
7
% F
% Gly:
0
0
0
0
0
7
7
0
0
7
0
0
0
14
0
% G
% His:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
7
0
0
0
0
0
7
0
7
0
0
0
0
7
0
% I
% Lys:
40
14
14
7
14
14
0
0
7
7
14
14
0
0
7
% K
% Leu:
0
0
0
7
7
27
7
7
7
7
0
0
7
0
14
% L
% Met:
0
0
0
14
0
0
0
7
0
0
0
0
7
0
0
% M
% Asn:
0
0
7
7
0
0
0
7
0
0
0
7
7
0
0
% N
% Pro:
0
0
0
0
14
7
0
7
0
0
0
0
0
0
14
% P
% Gln:
0
7
0
0
0
0
7
0
0
0
7
7
0
0
0
% Q
% Arg:
7
0
0
14
0
7
0
0
0
0
7
7
0
0
0
% R
% Ser:
0
0
14
7
14
14
20
34
7
14
7
27
34
7
14
% S
% Thr:
7
7
27
7
0
0
0
14
7
7
0
0
7
7
14
% T
% Val:
0
7
7
14
0
0
0
0
0
7
0
0
7
14
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
14
0
0
0
0
14
0
7
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _